An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity Q12 Laura Baseler,*y Darryl Falzarano,* Dana P. Scott,z Rebecca Rosenke,z Tina Thomas,* Vincent J. Munster,* Heinz Feldmann,* and Emmie de Wit* Q1 Q2 From the Laboratory of Virology,* and the Rocky Mountain Veterinary Branch,z Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Rocky Mountain Laboratories, Hamilton, Montana; and the Department of Comparative Pathobiology,y Purdue University, West Lafayette, Indiana Accepted for publication October 27, 2015. Address correspondence to Emmie de Wit Q5 , Rocky Moun- tain Laboratories, 903 S Fourth St, Hamilton, MT 59840. E-mail: emmie.