1 Molecular mechanism for PEDV entry Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases Chang Liu 1, #, Yuanmei Ma 2, #, Yang Yang 1, #, Yuan Zheng 1, Jian Shang 1, Yusen Zhou 3, Shibo Jiang 4, 5, Lanying Du 4, Jianrong Li 2, *, Fang Li 1, * From 1 Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA 2 Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA 3 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China 4 Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA 5 Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, School of Basic Medicine, Fudan University, Shanghai 200032, China #These authors contributed equally to this work. To whom correspondence should be addressed: (1) Fang Li, Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, Telephone: (612) 625-6149; Fax: (612) 625-8408; Email: