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2017 Binding of the Methyl Donor_ _i_S__i__ -Adenosyl-l-Methionine to Middle East Respiratory PDF
58 Pages
2017
4.01 MB
EnglishPreview 2017 Binding of the Methyl Donor_ _i_S__i__ -Adenosyl-l-Methionine to Middle East Respiratory
Binding of the methyl donor SAM to MERS-CoV 2'-O- 1 methyltransferase nsp16 promotes the recruitment of the allosteric 2 activator nsp10. 3 4 5 Short title: MERS-CoV 2'-O-methyltransferase allosteric regulation 6 7 8 Wahiba Aouadia,b, Alexandre Blanjoiec, Jean-Jacques Vasseurc, Françoise 9 Debartc, Bruno Canarda,b and Etienne Decrolya,b,# 10 11 aAix-Marseille Université, AFMB UMR 7257, 163 avenue de Luminy, 13288 12 Marseille cedex 09, France 13 bCNRS, AFMB UMR 7257, 163 avenue de Luminy, 13288 Marseille cedex 09, 14 France 15 cIBMM, UMR 5247 CNRS, UM, ENSCM, Department of Nucleic Acids, 16 Montpellier University, Place E. Bataillon, 34095 Montpellier Cedex 05, France 17 #Corresponding author: Etienne Decroly,
