Combinatorial chemistry and molecular diversity approaches to  scientific inquiry and novel product R&D have exploded in the  1990s! For example, in the preparation of drug candidates, the  automated, permutational, and combinatorial use of chemical building  blocks now allows the generation and screening of unprecedented  numbers of compounds. Drug discovery - better, faster, cheaper?  Indeed, more compounds have been made and screened in the 1990s than  in the last hundred years of pharmaceutical research.   This first volume covers: (i) combinatorial chemistry, (ii)  combinatorial biology and evolution, and (iii) informatics and related  topics. Within each section chapters are prepared by experts in the  field, including, for example, in Section I: Coverage of mixture pools  vs. parallel individual compound synthesis, solution vs.  solid-phase synthesis, analytical tools, and automation.  Section II highlights selection strategies and library-based  evolution, phage display, peptide and nucleic acid libraries. Section  III covers databases and library design, high through-put screening,  coding strategies vs. deconvolutions, intellectual property issues,  deals and collaborations, and successes to date.

Annual Reports in Combinatorial Chemistry and Molecular Diversity Volume 1 (Annual Reports in Combinatorial Chemistry & Molecular Diversity) PDF

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