Antibacterial coatings based on sonochemically designed surface metal nanofoams, 2011, CLG 984267 NATO Science for Peace and Security (SPS) Programme Workshop on CBRN Defence – 22-24 October 2013 – Brussels Emerging Security Challenges Division NATO Brussels, Belgium, 22.10.2013 1 Project Description Antibacterial coatings based on sonochemically designed surface metal nanofoams, 2011, CLG 984267 • General overview: Advances for a new generation of active metal surfaces with feedback properties. • Objectives: Technologies for fabrication of surface metal nanofoams for active chemicals storage by “green” ultrasound irradiation with combination with self- assembly complexation between biocide and polyelectrolyte in open/close states and formation of surface nanoreservoirs capable of long-term storage and controllable release of the entrapped antimicrobial agents which provide a basis for novel CNBR decontamination coatings. • Expected outcomes comprehensible to the non-expert: fabrication of surface encapsulation systems capable of long-term storage and controllable release of the entrapped antimicrobial agents which provide a basis for novel CNBR decontamination coatings. 2 What did we want to achieve ? Nanoengineered Cavitation Interfaces Understanding and controlling of sonochemical reaction at solid surfaces → boost fundamental research, control of nucleation Bio-active Surface Rational interface design inorganic / polymeric / biological → antifouling systems, new medical therapies for human transplants, stem-cell research 3 What is special in sonochemistry? “Hot spot” theory  High Energy  Fast  Localised  Sonoparameters → easy way to various structures  Red/Ox vis-à-vis reaction in liquid  Additive in liquid → single-step hybrids 4 Focused ultrasonic treatment * Lower left inset shows multibubble sonoluminecence ** Right inset shows ultrasonic unit for sonochemical modification, where 1) piezoceramic transducer; 2) booster; 3) irradiating horn; 4) gas inlet; 5) thermoelement; 6) thermostated sonocell. 5 Cavitation assisted porous surfaces  Surface capsules could be formed at higher intensity of sonication 6 Surface capsules on metal surface 7 Design of intelligent surfaces TEM ultramicrocut of sonomodified metal 8 Types of capsules 9 Surface pore loading “Surface” drug delivery: stimuli-responsive, controlled, extended, multi-drug, with biosensing 10