Cholesterol is an essential component of the plasma membrane Phosphatidylinositol 4 5 bisphosphate PI 4 5 P2 although a minor phospholipid is the most abundant membrane phosphoinositide Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function Studies on these important lipids have traditionally focused on the effect of each lipid individually Accumulating evidence indicates however that these lipids may cross regulate each other s levels Furthermore it is becoming evident that cholesterol and PI 4 5 P2 can act together to modulate protein function and biological processes This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI 4 5 P2 functions extend from parallel existence to crosstalk It includes four sections The first section introduces the reader to cholesterol and PI 4 5 P2 The second section demonstrates the mutual influence of these two critical lipids on their levels The third section divided into two parts describes the co modulation of protein function by cholesterol and PI 4 5 P2 The first part focuses on ion channels and the second on lipid transfer proteins The fourth section highlights other cellular processes at the intersection of cholesterol and PI 4 5 P2 involvement Collectively the book portrays the emerging relationship between cholesterol and PI 4 5 P2 in a broad array of biological systems and processes The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems as well as graduate students postdoctoral trainees basic and clinical researchers and pharmaceutical scientists Specifically the content will be relevant to researchers in the fields of biochemistry molecular biophysics pharmacology neurobiology cardiovascular biology among others Provides a comprehensive overview of the current knowledge of the interplay between cholesterol and PI 4 5 P2 Provides an overview of the emerging relationship between cholesterol and PI 4 5 P2 in biological systems and processes Discusses cellular processes and molecular mechanisms where lipid functions extend from parallel existence to crosstalk

Cholesterol and PIP2 in Vital Biological Functions PDF

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