Over 500 prokaryotic genomes have been sequenced to date, and thousands more  have been planned for the next few years. While these genomic sequence data  provide unprecedented opportunities for biologists to study the world of  prokaryotes, they also raise extremely challenging issues such as how to  decode the rich information encoded in these genomes. This comprehensive  volume includes a collection of cohesively written chapters on prokaryotic  genomes, their organization and evolution, the information they encode, and  the computational approaches needed to derive such information. A comparative  view of bacterial and archaeal genomes, and how information is encoded  differently in them, is also presented. Combining theoretical discussions and  computational techniques, the book serves as a valuable introductory textbook  for graduate-level microbial genomics and informatics courses.    Contents: General Characteristics of Prokaryotic Genomes (J Mr??zek & A O  Summers); Genes in Prokaryotic Genomes and Their Computational Prediction (R K  Azad); Evolution of the Genetic Code: Computational Methods and Inferences (G  Fournier); Dynamics of Prokaryotic Genome Evolution (P Lapierre); Mobile  Genetic Elements and Their Prediction (M G I Langille et al.); Horizontal Gene  Transfer: Its Detection and Role in Microbial Evolution (J P Gogarten & O  Zhaxybayeva); Genome Reduction During Prokaryotic Evolution (F J Silva & A  Latorre); Comparative Mechanisms for Transcription and Regulatory Signals in  Archaea and Bacteria (A Mart?­nez-Antonio & J Collado-Vides); Computational  Techniques for Orthologous Gene Prediction in Prokaryotes (M Poptsova);  Computational Elucidation of Operons and Uber-Operons (P Dam et al.);  Prediction of Regulons Through Comparative Genome Analyses (Z-C Su et al.);  Prediction of Biological Pathways Through Data Mining and Information Fusion  (F-L Mao et al.); Microbial Pathway Models (S R Veflingstad et al.);  Metagenomics (K Arima & J Wooley).

Computational Methods for Understanding Bacterial and Archaeal Genomes (Series on Advances in Bioinformatics and Computational Biology) PDF

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