YALE UNIVERSITY CUSHING/WHITNEY MEDICAL LIBRARY Digitized by the Internet Archive in 2017 with funding from Arcadia Fund https://archive.org/details/functionalgenomiOOIaur FUNCTIONAL GENOMICS OF KRIT1, THE GENE MUTATED IN CEREBRAL CAVERNOUS MALFORMATION A Thesis Submitted to the Yale University School of Medicine In Partial Fulfillment of the Requirements for the Degree of Doctor of Medicine By Maxwell S. H. Laurans Thesis Advisors: Murat Gunel, M.D., and Richard P. Lifton M.D., Ph.D. May 2003 f Yi^ YALE MEDICAL LIBRARY AUG 1 1 Z003 70Z7