What are the main challenges of computational molecular biology once the                  genome projects are completed? Integrative Approaches to Molecular Biology focuses                  on molecular biology beyond sequences: from gene regulation to differentiation, a                  higher-level integration that will be a major theme in biology following conclusion                  of the genome program. It charts the course of the emerging discipline of                  integrative molecular biology from macromolecular sequences to a biological (and                  theoretical) perspective, showing that novel integrative methodologies and paradigms                  are emerging at the confluence of such disciplines as computer science, logic,                  linguistics, and mathematics.Following an introductory chapter by Richard Lewontin                  that offers a critique of the evolutionary process as one of engineering design, the                  first part of the book, on computational biology, addresses issues concerning                  protein and DNA sequences within genome projects and a federated infrastructure for                  databases. The second part brings together experimental, evolutionary,                  computational, and theoretical approaches dealing with regulation of gene                  expression, metabolic pathways, and cell differentiation. The book concludes with a                  chapter on problems and perspectives on artificial intelligence.

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