Intracellular antibody-bound pathogens stimulate immune signaling via Fc receptor TRIM21 McEwan et al. 2013 Presented by Jorge Dinis April 11th Wednesday, April 10, 2013 Wednesday, April 10, 2013 Wednesday, April 10, 2013 Wednesday, April 10, 2013 McEwan et al. show something magical. Wednesday, April 10, 2013 Wednesday, April 10, 2013 Fab Fc Wednesday, April 10, 2013 TRIM21 TRIM21 Wednesday, April 10, 2013 Wednesday, April 10, 2013 TNF LT-(cid:96) TNFR1 LT-(cid:96)R Cytoplasm TAK1 P P IKK(cid:95) IKK(cid:96) IKK(cid:95) P P p50-p65 p100-RelB B (cid:103) I Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub p50-p65 p100-RelB Proteasome Proteasome B (cid:103) I Nucleus PTM p50-p65 p52-RelB Wednesday, April 10, 2013