A blueprint for the investigation of neurodevelopmental disorders, this                  book presents the work of a team of scientists using a multidisciplinary, integrated                  approach to link genes with human behavior. Using Williams syndrome as a model,                  leading researchers in neuroanatomy, neurocognition, neurophysiology, and molecular                  genetics have built bridges between disciplines to link higher cognitive functions,                  their underlying neurobiological bases, and their molecular genetic underpinnings.                  One of the book's many strengths is that the scientists from each discipline studied                  the same individuals with Williams syndrome. As the book shows, Williams syndrome is                  a fascinating disorder because of the "peaks and valleys" among cognitive domains:                  severe intellectual deficits but remarkably spared and effusive language; specific                  impairment in spatial construction but great strength in face processing and                  sociability. By capitalizing on these dissociations in higher cognitive functioning,                  the book provides a model for the study of brain-behavior relationships as well as                  for the mapping of brain and behavior phenotypes to the genome and                  beyond.Contributors Ralph Adolphs, Twyla Alvarez, Lawrence Appelbaum, Ursula                  Bellugi, Dennis Burian, Xiao-Ning Chen, Michael Chiles, Stephan Eliez, Albert                  Galaburda, Hanao Hirota, Wendy Jones, Julie Korenberg, Zona Lai, Liz Lichtenberger,                  Alan Lincoln, Rumiko Matsuoka, Debra Mills, Helen Neville, Judy Reilly, Allan Reiss,                  Bruce Roe, Marie St. George, J. Eric Schmidtt, Erica Straus.

Journey from Cognition to Brain to Gene: Perspectives from Williams Syndrome PDF

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