Metallothioneins (MTs) represent a large family of proteins characterized by  high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine  abundance. They have a powerful protective function in all animal tissues, due  most likely to their properties as free radical scavengers protecting against  oxidative damage. Moreover, the presence and overexpression of MTs in various  pathological conditions, such as metal dyshomeostasis, cell proliferation,  neurological disorders, and chemotherapy and radiotherapy resistance, could be  used as an important prognostic marker, as a histopathological diagnostic  tool, and to follow specific pharmacological treatments.    This important book explores the role of MTs in the field of neurological  disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS,  etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma,  prostate and breast cancer), through authoritative contributions and a  description of basic biochemical information and paradigmatic pathological  events.    Contents:  Metallothionein in Neurological Disorders; Metallothionein in  Oncology; Metallothionein in Cardiopathy; Metallothionein in Hepatology.

Metallothioneins in Biochemistry and Pathology PDF

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