PNH and Thrombosis David J. Araten, MD Assistant Professor NYU School of Medicine Thrombosis and PNH • How blood clots form normally • How unwanted blood clots form • Consequences of abnormal blood clots • Sites of abnormal blood clots in PNH • Symptoms of blood clots • Why blood clots form in PNH • Treatment and prevention Tendency to clot inappropriately • Hypercoagulability • Hypercoagulable state • Thrombophilia • Thrombotic tendency • Pro-thrombotic state • Clotting tendency All mean the same thing Blood clot at the site of a broken vessel Red cells moving in a blood vessel Red cells caught in a web of fibrin Platelets Tissue factor fibrin