Y P Potential clinical applications of TMS inO pediatrics C T O N O D E Aaron Boes, MD, PhD S Sidney R. Baer Clinical Neuroscience Fellow, BIDMC A Pediatric Neurologist, MGH E L P Y P O C T O N Disclosure: Off-label uses of TMS will be discussed O D E S A E L P Y P O Topics C T Highlight of a few areas in which TMS may find clinical O applications in the pediatric population in the near future. N - Depression - Rehabilitation O - Epilepsy D - Autism E - ADHD S - Tourrettes A E L P Y P O C T O Please interrupt, ask questions. N O D E S A E L P Y P O Challenges and opportunities in pediatrics C T Neurodevelopmental disorders are common. 1 in 6 (Boyle, O 2011) N O D Neuropsychiatric disease = #1 worldwide cause of disability age 10-24 and overall (Lancet, 2011 & 2013) E S Current therapies are inadequate A E L P Y P O Current knowledge gap in clinical neurology and psychiatry… C Brain disorders currently conceptualizedT of in terms of dysfunctional networks (Bianchi, 2012) O N Diagnoses are based on behavior \ subjective symptoms, not network dysfunction. O D Therapy does not target dysfunctional networks. E S A E L P Y P Bridging the gap – Diagnosis and therapOy targeting dysfunctional networks C T O N O D E S A E L P Y P O Why Pediatrics – Why now? C T All neurodevelopmental disorders and almOost 2/3 of neuropsychiatric disorders manifest in the pediatric population N (Kessler, 2005) O Prevention or early diagnosis \ intervention leads to better outcomes. D E Research on adults may not apply to pediatric patients S A E L P Y P Interventions in younger people = better return oOn investment C T O N O D E S A E L P . Heckman, Science, 2006 Y P O C T O Depression N O > D E S A E L P