This book highlights proteasome structures and how they  are related to different aspects of proteasome function. Moreover, the  book reports on the functional roles these highly developed  proteolytic machines play within the cell. It was a great surprise to  the scientific world that proteolysis provides crucial functions in  cellular regulation. The surprise was even greater when it was found  that not lysosomes, but protease complexes with remarkably  sophisticated architectures were responsible for the control of  essential regulatory events. Excitingly, proteasomes were found to be  involved in widespread functions of cell physiology, which included  degradation of protein waste, antigen presentation, regulation of cell  metabolism and cell differentiation as well as control of the cell  cycle. The discovery of such multiple and essential functions made  investigation of proteasome mediated regulatory proteolysis a highly  significant theme in cell biology. Written by pioneers in the field  the book represents a comprehensive up-to-date view on proteasome  structures and functions from the ultimate frontier of cell biology  research. It ties the reader to all facets of cell function. This work  is an indispensable source for scientists working in the fields of  basic and applied cell biology and immunology. Different aspects of  proteasome functions are associated with the development of  detrimental diseases like cancer, neurodegeneration, cystic fibrosis  or immune disorders. Therefore, data reviewed in this book are  important for physicians and pharmacologists active in research, and  experts in the pharmaceutical industry.

Proteasomes : The World of Regulatory Proteolysis (Molecular Biology Intelligence Unit) PDF

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