Main Nomenclature and Earliest Clinical growth main histology onset correlation mechanism Initial lesion • Histologically “normal” • Macrophage infiltration • Isolated foam cells From 1st decade Fatty streak • Mainly intracellular lipid Clinically n accumulation silent o Growth mainly ti by lipid addition c Intermediate lesion n u • Intracellular lipid accumulation f s • Small extracellular lipid pools y D From 3rd l decade a Atheroma li e • Intracellular lipid accumulation h t • Core of extracellular lipid o d n E Fibroatheroma Increased smooth Clinically • Single or multiple lipid cores muscle and silent • Fibrotic/calcific layers collagen increase or overt From 4th decade Complicated lesion Thrombosis • Surface defect and/or • Hematoma-hemorrhage hematoma • Thrombosis