Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds.This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia.Contents:1 Organic Synthesis: General Remarks2 Stereoelectronic Effects and Reactivity3 The Stability of Organic Compounds4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles5 The Alkylation of Carbanions6 The Alkylation of Heteroatoms7 The Acylation of Heteroatoms8 Palladium-Catalyzed C-C Bond Formation9 Cyclizations10 Monofunctionalization of Symmetric Difunctional Substrates

Side Reactions in Organic Synthesis PDF

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