UUnniivveerrssiittyy ooff SSaalleerrnnoo UUnniivveerrssiittyy ooff TTuurrkkuu Department of Chemical Engineering Department of Biochemistry and Food Chemistry SSSSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll FFFFlllluuuuiiiiddddssss mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss RRRReeeennnnaaaattttaaaa AAAAddddaaaammmmiiii PhD student Dept. Biochemistry and Food Chemistry University of Turku FINLAND [email protected] Dept. Chemical and Food Engineering FINNISH CHEMICAL SOCIETY University of Salerno ITALY CCCCoooommmmpppprrrreeeesssssssseeeedddd fffflllluuuuiiiidddd tttteeeecccchhhhnnnnoooollllooooggggiiiieeeessss ddddiiiivvvviiiissssiiiioooonnnn [email protected] Seminar, Helsinki 23 November 2006 OOOOuuuuttttlllliiiinnnneeee SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss oSSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt oSSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee oSSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt oSSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt PPPPrrrroooodddduuuuccccttttiiiioooonnnn ooooffff mmmmiiiiccccrrrroooo SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss aaaannnndddd nnnnaaaannnnooooppppaaaarrrrttttiiiicccclllleeeessss mmmmiiiiccccrrrrooooppppaaaarrrrttttiiiicccclllleeeessss m m 1 m < d < 5 m products for aerosol d < 500 nm suspensions for injection nnnnaaaannnnooooppppaaaarrrrttttiiiicccclllleeeessss directly to the organs d < 200 nm iiiimmmmpppprrrroooovvvveeeemmmmeeeennnntttt ooooffff ssssoooolllluuuubbbbiiiilllliiiittttyyyy cccchhhhaaaarrrraaaacccctttteeeerrrriiiissssttttiiiiccccssss Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee TTTTrrrraaaaddddiiiittttiiiioooonnnnaaaallll PPPPrrrroooocccceeeesssssssseeeessss SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss large PSD Spray-drying high Temperature large PSD Jet-milling compounds denaturation large PSD Liquid Antisolvent Crystallization residual solvents Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt SSSSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll FFFFlllluuuuiiiiddddssss SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss ggggaaaassss----lllliiiikkkkeeee lllliiiiqqqquuuuiiiidddd----lllliiiikkkkeeee BBBBeeeesssstttt ccccoooonnnnttttrrrroooollll ooooffff PPPPSSSS PPPPSSSSDDDD HHHHiiiigggghhhh ddddiiiiffffffffuuuussssiiiivvvviiiittttyyyy HHHHiiiigggghhhh ddddeeeennnnssssiiiittttyyyy LLLLoooowwww vvvviiiissssccccoooossssiiiittttyyyy Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt SSSSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll FFFFlllluuuuiiiiddddssss bbbbaaaasssseeeedddd SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss MMMMiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn PPPPrrrroooocccceeeesssssssseeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt RREESSSS RRaaaappppiiiidddd EExxxxppppaaaannnnssssiiiioooonnnn ooooffff SSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll SSoooolllluuuuttttiiiioooonnnn SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee ®® PPGGSSSS PPaaaarrrrttttiiiicccclllleeeessss ffffrrrroooommmm GGaaaassss----SSaaaattttuuuurrrraaaatttteeeedddd SSoooolllluuuuttttiiiioooonnnnssss Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt SSSSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll FFFFlllluuuuiiiiddddssss bbbbaaaasssseeeedddd SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss MMMMiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn PPPPrrrroooocccceeeesssssssseeeessss SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt ®® DDEELLOOSS DDeeeepppprrrreeeessssssssuuuurrrriiiizzzzaaaattttiiiioooonnnn ooooffff aaaannnn EExxxxppppaaaannnnddddeeeedddd LLiiiiqqqquuuuiiiidddd OOrrrrggggaaaannnniiiicccc SSoooolllluuuuttttiiiioooonnnn ®® CCaaaarrrrbbbboooonnnn ddddiiiiooooxxxxiiiiddddeeee AAssssssssiiiisssstttteeeedddd CCAANN--BBDD NNeeeebbbbuuuulllliiiizzzzaaaattttiiiioooonnnn wwwwiiiitttthhhh aaaa BBuuuubbbbbbbblllleeee DDrrrryyyyeeeerrrr ®® SSAAAA SSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll AAssssssssiiiisssstttteeeedddd AAttttoooommmmiiiizzzzaaaattttiiiioooonnnn Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt SSSSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll FFFFlllluuuuiiiiddddssss bbbbaaaasssseeeedddd SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss MMMMiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn PPPPrrrroooocccceeeesssssssseeeessss SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt PPCCAA PPrrrreeeecccciiiippppiiiittttaaaattttiiiioooonnnn wwwwiiiitttthhhh CCoooommmmpppprrrreeeesssssssseeeedddd AAnnnnttttiiii----ssssoooollllvvvveeeennnnttttssss GGAASS GGaaaassss AAnnnnttttiiii----SSoooollllvvvveeeennnntttt AASSEESS AAeeeerrrroooossssoooollll SSoooollllvvvveeeennnntttt EExxxxttttrrrraaaaccccttttiiiioooonnnn SSyyyysssstttteeeemmmm SSEEDDSS SSoooolllluuuuttttiiiioooonnnn----EEnnnnhhhhaaaannnncccceeeedddd DDiiiissssppppeeeerrrrssssiiiioooonnnn bbbbyyyy SSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll fffflllluuuuiiiiddddssss SSuuuuppppeeeerrrrccccrrrriiiittttiiiiccccaaaallll AAnnnnttttiiii----SSoooollllvvvveeeennnntttt SSAASS Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt RRRREEEESSSSSSSS SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss cccchhhhaaaarrrraaaacccctttteeeerrrriiiissssttttiiiiccccssss solubility of the compound in the SCF morphology of the product depends on material structure and operative parameters no use of organic solvents limits for applications: many attractive substrates not enough soluble into the SCF Renata Adami 15.12.2006 SSSSCCCCFFFF aaaannnndddd mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn tttteeeecccchhhhnnnniiiiqqqquuuueeeessss SSSSCCCCFFFF aaaassss aaaa ssssoooollllvvvveeeennnntttt RRRREEEESSSSSSSS SSSSCCCCFFFF aaaassss aaaa ssssoooolllluuuutttteeee SSSSCCCCFFFF aaaassss aaaa ccccoooo----ssssoooollllvvvveeeennnntttt SSSSCCCCFFFF aaaassss aaaannnn aaaannnnttttiiii----ssssoooollllvvvveeeennnntttt SSSSAAAASSSS mmmmiiiiccccrrrroooonnnniiiizzzzaaaattttiiiioooonnnn aaaappppppppaaaarrrraaaattttuuuussss PPPRRREEECCCIIIPPPIIITTTAAATTTIIIOOONNN UUUNNNIIITTT EEEXXXTTTRRRAAACCCTTTIIIOOONNN UUUNNNIIITTT pppuuummmppp EEExxxpppaaannnsssiiiooonnn vvveeesssssseeelll AAAccctttiiivvveee sssuuubbbssstttaaannnccceee CCOO 22 Renata Adami 15.12.2006