Wl Libraries THE Case THE OF Frozen Addicts THE Case OF THE Frozen Addicts WILLIAM LANGSTON, M.D. J. JON PALFREMAN and Pantheon Books New York Undergraduate Copyright©1995byJ. WilliamLangstonandJonPalfreman AllrightsreservedunderInternationalandPan-AmericanCopyright Conventions. PublishedintheUnitedStatesbyPantheonBooks, a divisionofRandomHouse,Inc.,NewYork,andsimultaneouslyin CanadabyRandomHouseofCanadaLimited,Toronto. LibraryofCongressCataloging-in-PublicationData Langston,J. W. (JamesWilliam) Thecaseofthefrozenaddicts/J. WilliamLangstonandJon Palfreman. p. cm. Includesindex. ISBN0-679-42465-2 — 1. Parkinsonism Casestudies. 2. — Methylphenyltetrahydropyridine Physiologicaleffect. 3. Designer — — — drugs Toxicology. 4. Fetaltissues Transplantation Case — studies. 5. Parkinsonism Animalmodels. I. Palfreman,Jon. II. Title. — — [DNLM: 1.Parkinson'sdisease therapy casestudies. 2. Fetal — tissuetransplantation casestudies. 3. Braintissue — transplantation casestudies. 4.Substantia — — nigra embryology casestudies. 5.Substantia — — nigra transplantation casestudies. WL 359L295c 1995] RC382.L37 1995 616.8'33—dc20 94-43202 GIF BookdesignbyChrisWelch ManufacturedintheUnitedStatesofAmerica First Edition 987654 21 3 To Connie, George, Juanita, David, Bill, and Toby Digitized by the Internet Archive 2010 in http://www.archive.org/details/caseoffrozenadcliOOIang