The traditional model of synapses as fixed structures has been replaced                  by a dynamic one in which synapses are constantly being deleted and replaced. This                  book, written by a leading researcher on the neurochemistry of schizophrenia,                  integrates material from neuroscience and cell biology to provide a comprehensive                  account of our current knowledge of the neurochemical basis of synaptic                  plasticity.The book presents the evidence for synaptic plasticity, an account of the                  dendritic spine and the glutamate synapse with a focus on redox mechanisms, and the                  biochemical basis of the Hebbian synapse. It discusses the role of endocytosis,                  special proteins, and local protein synthesis. Additional topics include volume                  transmission, arachidonic acid signaling, hormonal modulation, and psychological                  stress. Finally, the book considers pharmacological and clinical implications of                  current research, particularly with reference to schizophrenia and Alzheimer's                  disease.

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