This concise and easy to read book is essentialy a crash course in single particle reconstruction by electron microscopy.  It isn't exactly a how-to manual, more an overview of how the whole process works.  Thus, it is useful not only to someone who wants to learn how to do this, but also to those who might be interested in deciding if this technique would be useful to them.  And actually, the whole topic is sufficiently cool that I would recommend the book even to people who know they will never use this technique, just because its fun to read about it.  The book is clearly written and doesn't assume alot of prior knowledge.  A basic undergrad education in math would be enough to handle the equations.

Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State PDF

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